WISE (Women's Ischemia Syndrome Evaluation) is an NHLBI sponsored, four center study to evaluate innovative diagnostic methods that will improve the diagnostic reliability of cardiovascular testing in evaluation of ischemic heart disease in women. Innovative approaches to evaluate myocardial ischemia will include physiologic and functional measurements such as impaired metabolism, perfusion, or endothelial function as well as assessment of epicardial coronary arteries by angiography methods. Women will be followed by telephone yearly to assess coronary events and symptoms.