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Polymyositis and dermatomyositis are inflammatory muscle disorders of unknown etiology currently classified under the rubric of idiopathic inflammatory myopathy (IIM). All forms of IIM are characterized by muscle weakness as well as striated muscle inflammation. The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) at the National Institutes of Health is sponsoring the first international multi-center trial to be conducted in both adult and juvenile myositis patients. This multi-center trial will examine the effectiveness of rituximab, a novel biologic agent. This study will be directed and coordinated by Dr. Chester Oddis in the Division of Rheumatology and Clinical Immunology at the University of Pittsburgh School of Medicine and Dr. Ann Reed, Chair Pediatric Rheumatology, Mayo Foundation and School of Medicine at the Mayo Clinic.

- Recruitment has ended for this study. -